PRP + Light Therapy: Powerful Healing Breakthrough (2025)

This week we've got quite a lot of new mask content out. We're also considering a combination of two therapies, light therapy and "Platelet Rich Plasma" (PRP), which is also taking the world of medicine by storm.

Check the lastest news below:

Nov 2025 Study: Platelet Rich Plasma (PRP) Combined With Light Therapy For A Huge Wound Healing Boost

PRP is derived from your own blood, by taking it out of your body. What happens next is that the platelets and growth factors are concentrated outside the body. The PRP is then reinjected into the injured area to stimulate healing or just to plain improve cellular functioning. So you can use PRP to heal but also for anti-aging purposes...

Next up, consider the Nov 2025 study. In this case, the goal was wound healing (of a diabetic foot ulcer) and so-called "osteomyelitis", which is a bone infection. You can read the Nov 2025 full text for free.

Many people with diabetes have peripheral problems on their feet, as a side effect of the condition, due to poor blood flow, for instance. We've written extensively about light therapy for diabetes in the past, which you can check here:

The Nov 2025 study is a "case study", meaning that it doesn't follow the gold standard in medicine with a placebo and intervention group. Instead, the researchers describe in detail what the study participants underwent.

In this case, 20 people in total were included in the study. Two of them were singled out and described in a lot of detail. Below you can see an example of a foot ulcer on the heel of a diabetes patient:

But let's take a step back:

Diabetic Foot Ulcers, also called "DFUs" are open wounds. These wounds develop most often on the bottom of the foot in people with diabetes. DFUs are problematic for several reasons. First, high blood sugar damages nerves (and you can end up with neuropathy). Secondly, blood sugar damages blood vessels. Due to the neuropathy, sensation is lost, so you don't feel that damage is taking place like a normal wound.

The poor blood flow also causes poor immunity and slow healing in the feet. Infection risk goes up. And, without sensation, you can easily end up with other tissues being damaged, such as bones, tendons, etc - which is a risk in the picture listed above. This damage can be permanent...

No bueno!

But let's go back to the two main study participants who were watched really closely in this study. Researchers write that:

"The first case involves a 65‐year‐old male with a chronic heel ulcer unresponsive to conventional therapies. The second case is a 58‐year‐old female with a necrotic toe and persistent ulceration. Treatment consisted of multiple sessions of laser and plasma therapy, integrated with standard wound care protocols. Progress was monitored through wound size, tissue regeneration, infection control, and overall healing response"

The study participants needed the light therapy and PRP because traditional wound care methods were insufficient. The good news? Here's what the researchers write about the outcome:

- Across all cases, improvements were observed in granulation tissue formation, infection control and overall wound healing progression.

- The dual‐modality treatment helped avoid surgical interventions in several instances.

- This approach highlights the potential role of laser and plasma as valuable adjuncts in the multidisciplinary management of complex diabetic wounds.

Unfortunately, the treatment protocol with light isn't described too well, except that it's a red laser, and that 6J of energy was applied at the margins of the ulcer, 2J directly at the ulcer, and 4J at adjacent areas. The researchers used a 200 mW laser, which isn't super powerful - so you can recreate somewhat similar situations in your home with a handheld device, for instance, if you turn off the near-infrared light.

For PRP injections? The researchers collected 2-4 mL of blood from the study participants. The blood was then mixed with an anticoagulant. The blood was then centrifuged for 10-15 minutes (a quick spinning motion). The blood plasma was then injected into the wound within 15 minutes. The injections were done in part of the wound that hadn't healed properly yet.

Here you can see a good overview of the entire process:

The participants also received standard-of-care measures, such as wound dressings and cleaning. So this procedure is not a replacement for standard wound care!

Now, the not-so good looking wounds of the participant 1 - hope you have a strong stomach:

Open Source, Creative Commons 4.0 License, source

As you can see, the wound was necrotic early on, meaning that the tissue was dying off, which is dangerous for infections and tissue damage nearby such as the bone. But, fortunately, there's quick progress and after one month, the wound has closed off a lot more and all of the nectrotic tissue (black) is gone. After two months, the full ulcer was healing and no longer necrotic.

The second case is even worse looking but also healed over time, with the red laser and PRP injection combination:

Keep in mind that this procedure can be life-saving, or limb-saving at the very least, as often, as the wound progresses, the entire foot needs to be amputated. Amputation often is the course of action here, as infection risk goes up dramatically with a big wound and you can die. When looking at data, there's a 31% amputation rate generally with people with diabetic foot ulcers. So we're in desperate need of better treatment modalities here.

The conclusion? Here's what researchers write:

"This study also aims to serve the same purpose; technologies such as laser and plasma therapy may represent a valuable adjunct to standard wound care. Remarkably, all 20 patients in this article experienced full wound healing following the application of this dual therapy, with no adverse effects or need for surgical intervention. This outcome strongly suggests that the synergy between laser and plasma therapy may provide a highly effective and safe alternative for managing chronic DFUs."

So, all 20 participants healed, not just the two that were described in detail in the study. We already knew that light therapy can dramatically improve healing rate, and that of hard-to-heal wounds, by up to 100% when applied correctly. But, this process can potentially be augmented even further with PRP injections.

Of course, we need more studies on this topic to verify these claims. Ideally, you'll have the Gold Standard of medicine, an Randomized Controlled Trial (RCT), with a placebo and intervention group, investigate this outcome. One group there would receive light treatment only, and the other light therapy plus PRP, to distinguish the effects between the two. Maybe a separate control group with standard of care (cleaning, bandaging, etc) would be great too.

Also, keep in mind that PRP is not super costly. You're just using your own blood for healing and growth factors, and then locally injecting those when they are separated.

On a side note, we've talked to some doctors who had extremely good effects with PRP and light therapy, as a combination. We'll likely interview these doctors in the future as the results are mind-boggling in some cases. Examples here are healing the cartilage in the knee, when the PRP injections are applied there locally, which shouldn't be possible according to the consensus in medicine right now.

With regard to the study, we'd loved to have more data on how precisely the light therapy was applied, such as the wavelenght, device, power density in mW/cm2, etc. So the study is far from perfect, but, it does hint at very strong effects that can be achieved with the PRP and light therapy combination.

Here Are Our Latest Light Therapy Insiders' Articles:

Every single article that we've published recently - you can find the videos in the article itself:

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